Motif ID: HOX{A4,D4}.p2

Z-value: 1.451


Transcription factors associated with HOX{A4,D4}.p2:

Gene SymbolEntrez IDGene Name
HOXA4 3201 homeobox A4
HOXD4 3233 homeobox D4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXA4chr7_-_27170351-0.481.1e-13Click!


Activity profile for motif HOX{A4,D4}.p2.

activity profile for motif HOX{A4,D4}.p2


Sorted Z-values histogram for motif HOX{A4,D4}.p2

Sorted Z-values for motif HOX{A4,D4}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A4,D4}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_-_34243118 42.454 RBM12
RNA binding motif protein 12
chr10_+_28878666 31.705 WAC
WW domain containing adaptor with coiled-coil
chr10_+_11047253 30.233 NM_001025077
CELF2
CUGBP, Elav-like family member 2
chr2_+_172821874 29.669 HAT1
histone acetyltransferase 1
chr17_+_18768781 28.741 NM_001243940
PRPSAP2
phosphoribosyl pyrophosphate synthetase-associated protein 2
chr21_+_30400229 26.371 USP16
ubiquitin specific peptidase 16
chr17_+_48821106 21.488 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr10_+_11047274 20.354 CELF2
CUGBP, Elav-like family member 2
chr9_-_86584079 20.035 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr2_+_109204904 19.224 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chr1_+_167298280 16.545 NM_001198783
POU2F1
POU class 2 homeobox 1
chr11_-_67450536 16.292 RPL37
ribosomal protein L37
chr10_-_27057776 15.893 ABI1
abl-interactor 1
chr3_+_63884074 15.296 NM_001177387
ATXN7
ataxin 7
chr12_-_46633551 15.234 SLC38A1
solute carrier family 38, member 1
chr1_+_84630575 14.996 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr13_-_41593405 14.946 ELF1
E74-like factor 1 (ets domain transcription factor)
chr1_+_40735749 14.432 ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr2_-_225370687 14.166 CUL3
cullin 3
chr9_+_79968344 13.864 VPS13A
vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr3_-_25683825 13.655 TOP2B
topoisomerase (DNA) II beta 180kDa
chr2_-_20527120 12.794 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chrX_+_70765479 12.384 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr2_-_20512016 12.332 PUM2
pumilio homolog 2 (Drosophila)
chr2_+_109204777 11.922 LIMS1
LIM and senescent cell antigen-like domains 1
chr1_-_207095198 11.630 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr19_-_42806928 11.625 NM_001145939
NM_001145940
PAFAH1B3

platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)

chr4_-_84035888 11.541 PLAC8
placenta-specific 8
chr14_+_70236266 11.455 SRSF5
serine/arginine-rich splicing factor 5
chr10_+_111765725 11.305 NM_019903
ADD3
adducin 3 (gamma)
chr6_-_32812711 11.142 NM_004159
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr3_+_63953419 11.034 NM_001128149
ATXN7
ataxin 7
chr13_-_41593491 10.515 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr4_-_84035908 10.446 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr17_+_41158741 10.393 NM_005533
IFI35
interferon-induced protein 35
chr9_+_33026482 10.331 DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chrX_-_135962872 10.182 RBMX
RNA binding motif protein, X-linked
chr6_-_24719286 10.178 NM_030939
C6orf62
chromosome 6 open reading frame 62
chr10_-_120938337 10.158 NM_006793
NM_014098
PRDX3

peroxiredoxin 3

chr12_+_64803741 10.136 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr5_-_168271852 9.926


chr1_-_108231122 9.922 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr2_-_43453737 9.781 NM_006887
ZFP36L2
zinc finger protein 36, C3H type-like 2
chr8_+_26150731 9.742 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chrX_-_135962929 9.713 NM_001164803
NM_002139
RBMX

RNA binding motif protein, X-linked

chr1_+_53480573 9.523 NM_001007099
NM_001007100
NM_001007250
SCP2


sterol carrier protein 2


chr3_-_156878481 9.494 NM_020307
CCNL1
cyclin L1
chr1_+_53480616 9.299 SCP2
sterol carrier protein 2
chr10_-_116392099 9.170 ABLIM1
actin binding LIM protein 1
chr17_+_26794838 9.141


chr4_-_151770611 9.124 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr20_+_44518782 8.764 CTSA
cathepsin A
chr6_-_75970566 8.756 TMEM30A
transmembrane protein 30A
chr22_+_31366662 8.745


chr2_+_109204745 8.652 NM_004987
LIMS1
LIM and senescent cell antigen-like domains 1
chr2_-_43453146 8.444 ZFP36L2
zinc finger protein 36, C3H type-like 2
chr14_-_23426356 8.408 HAUS4
HAUS augmin-like complex, subunit 4
chr10_-_120938276 8.376 PRDX3
peroxiredoxin 3
chr1_-_147931877 8.294 FLJ39739
uncharacterized FLJ39739
chr14_+_56078735 8.265 KTN1
kinectin 1 (kinesin receptor)
chr1_+_167298382 8.245 POU2F1
POU class 2 homeobox 1
chr2_-_85637486 8.202 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr1_+_155658881 8.182 NM_001199849
NM_001199850
NM_001199851
NM_004632
NM_033657
DAP3




death associated protein 3




chr3_+_130569368 8.118 NM_001199180
NM_001199181
NM_001199182
ATP2C1


ATPase, Ca++ transporting, type 2C, member 1


chr1_-_155948934 8.117 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr22_-_42336222 8.034 NM_001110215
CENPM
centromere protein M
chr1_+_174843523 8.017 NM_001243763
RABGAP1L
RAB GTPase activating protein 1-like
chr5_+_147795459 7.830 FBXO38
F-box protein 38
chrX_-_100872926 7.815 NM_001009584
NM_001184768
NM_019007
ARMCX6


armadillo repeat containing, X-linked 6


chr1_+_155658898 7.810 DAP3
death associated protein 3
chr5_-_133561805 7.744 NM_002715
PPP2CA
protein phosphatase 2, catalytic subunit, alpha isozyme
chr2_+_87144737 7.690 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr12_+_54891522 7.688 NCKAP1L
NCK-associated protein 1-like
chr14_-_23426265 7.664 NM_001166269
NM_001166270
NM_017815
HAUS4


HAUS augmin-like complex, subunit 4


chr4_+_39063851 7.652 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr3_+_107241782 7.607 NM_001142568
NM_020235
BBX

bobby sox homolog (Drosophila)

chr12_-_121785652 7.575 ANAPC5
anaphase promoting complex subunit 5
chr1_+_155658873 7.450 DAP3
death associated protein 3
chr6_+_64356430 7.379 NM_015153
PHF3
PHD finger protein 3
chr20_+_1093905 7.362 NM_178578
PSMF1
proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
chr18_+_32556891 7.331 NM_001143826
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr3_+_69134057 7.274 NM_006407
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr7_+_115863004 7.145 NM_152829
TES
testis derived transcript (3 LIM domains)
chr3_+_172472246 7.114 NM_018098
ECT2
epithelial cell transforming sequence 2 oncogene
chr17_-_48785016 7.114 NM_052855
ANKRD40
ankyrin repeat domain 40
chr12_+_54891539 7.100 NCKAP1L
NCK-associated protein 1-like
chr9_-_15510899 7.073 NM_001128217
NM_033222
PSIP1

PC4 and SFRS1 interacting protein 1

chr2_+_228192227 7.062 NM_020194
MFF
mitochondrial fission factor
chr10_-_98321823 7.051 TM9SF3
transmembrane 9 superfamily member 3
chr9_+_131447364 7.035 NM_001248000
SET
SET nuclear oncogene
chr17_-_38978824 7.029 NM_000421
KRT10
keratin 10
chr6_+_87969619 7.022 ZNF292
zinc finger protein 292
chr13_-_37679800 6.991 NM_145203
CSNK1A1L
casein kinase 1, alpha 1-like
chr4_+_2627158 6.946 NM_003704
FAM193A
family with sequence similarity 193, member A
chr4_+_170581212 6.892 NM_001243374
CLCN3
chloride channel 3
chrX_-_107334749 6.874 NM_002814
NM_170750
PSMD10

proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

chr19_-_20607761 6.861 ZNF826P
zinc finger protein 826, pseudogene
chr12_+_54891491 6.857 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr6_-_74229094 6.819 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr6_+_12717036 6.768 NM_001242648
NM_030948
PHACTR1

phosphatase and actin regulator 1

chr20_-_45976626 6.736 ZMYND8
zinc finger, MYND-type containing 8
chr6_+_34206567 6.556 NM_145905
HMGA1
high mobility group AT-hook 1
chr15_-_55563091 6.491 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chr13_-_50367027 6.452 NM_002267
KPNA3
karyopherin alpha 3 (importin alpha 4)
chr15_+_100173182 6.437 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr2_+_170662044 6.424 SSB
Sjogren syndrome antigen B (autoantigen La)
chr1_-_144520918 6.417 LOC728855
uncharacterized LOC728855
chr10_+_112344076 6.303 SMC3
structural maintenance of chromosomes 3
chr2_-_152146373 6.281 NM_004688
NMI
N-myc (and STAT) interactor
chr20_+_3776385 6.266 NM_004358
NM_021872
NM_021873
CDC25B


cell division cycle 25 homolog B (S. pombe)


chr13_+_103459495 6.236 NM_001204425
BIVM-ERCC5
BIVM
BIVM-ERCC5 readthrough
basic, immunoglobulin-like variable motif containing
chr7_+_141438122 6.212 NM_003143
SSBP1
single-stranded DNA binding protein 1
chr2_+_242255365 6.206 SEPT2
septin 2
chr5_+_67586466 6.190 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr5_-_88119604 6.180 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr12_-_80307690 6.162 NM_001143886
PPP1R12A
protein phosphatase 1, regulatory subunit 12A
chr14_-_95608054 6.149 NM_030621
DICER1
dicer 1, ribonuclease type III
chr15_+_80352257 6.134 NM_001242913
ZFAND6
zinc finger, AN1-type domain 6
chr12_-_102512277 6.117 NM_024057
NUP37
nucleoporin 37kDa
chr6_-_38670829 6.114 GLO1
glyoxalase I
chrX_-_48980070 6.000 NM_015698
GPKOW
G patch domain and KOW motifs
chr12_-_121792011 5.995 NM_001137559
ANAPC5
anaphase promoting complex subunit 5
chr6_-_38670915 5.973 GLO1
glyoxalase I
chr11_-_104827421 5.966 NM_033306
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr12_-_50616425 5.938 NM_001113547
LIMA1
LIM domain and actin binding 1
chr12_-_122712019 5.900 NM_019887
NM_138929
DIABLO

diablo, IAP-binding mitochondrial protein

chr12_+_28410132 5.893 NM_018318
CCDC91
coiled-coil domain containing 91
chr13_-_24007822 5.875 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr14_-_55650348 5.867 DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr18_+_33234532 5.841 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr8_+_11665394 5.782 FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr8_-_101936521 5.776 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr17_+_28707495 5.666 NM_001199775
CPD
carboxypeptidase D
chr10_-_16859408 5.620 NM_012425
NM_152724
RSU1

Ras suppressor protein 1

chr11_-_118900078 5.606 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr1_+_148560846 5.554 NM_173638
NBPF15
neuroblastoma breakpoint family, member 15
chr4_-_99851785 5.423 NM_001130679
NM_001968
EIF4E

eukaryotic translation initiation factor 4E

chr15_-_55562483 5.391 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr6_-_38670904 5.353 GLO1
glyoxalase I
chr5_+_132406080 5.339 HSPA4
heat shock 70kDa protein 4
chr7_+_77469446 5.335 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr9_+_75766777 5.322 NM_000700
ANXA1
annexin A1
chr9_+_75766794 5.314 ANXA1
annexin A1
chr5_-_145562068 5.273 LARS
leucyl-tRNA synthetase
chr16_-_28437663 5.272 NM_001199142
EIF3C
eukaryotic translation initiation factor 3, subunit C
chr12_+_56521953 5.256 NM_001184796
NM_015292
ESYT1

extended synaptotagmin-like protein 1

chrX_-_129272014 5.229 NM_001130846
AIFM1
apoptosis-inducing factor, mitochondrion-associated, 1
chr4_-_72649734 5.226 NM_000583
GC
group-specific component (vitamin D binding protein)
chr7_-_64023331 5.223 ZNF680
zinc finger protein 680
chr7_-_107204705 5.186 NM_001161520
NM_006348
NM_181733
COG5


component of oligomeric golgi complex 5


chr16_+_50321822 5.141 NM_001114
ADCY7
adenylate cyclase 7
chr12_+_56522049 5.140 ESYT1
extended synaptotagmin-like protein 1
chr12_+_56522043 5.106 ESYT1
extended synaptotagmin-like protein 1
chr15_+_80352018 5.087 ZFAND6
zinc finger, AN1-type domain 6
chr5_+_88185257 5.077 RPS6
ribosomal protein S6
chr3_-_165555252 5.065 NM_000055
BCHE
butyrylcholinesterase
chr15_+_52201590 5.035 TMOD3
tropomodulin 3 (ubiquitous)
chr22_+_21128378 5.034 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr2_+_183582667 5.031 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr1_-_144520987 4.929 LOC728855
uncharacterized LOC728855
chr8_+_110346549 4.913 NM_001193557
NM_020189
ENY2

enhancer of yellow 2 homolog (Drosophila)

chr5_+_140566655 4.908 NM_019119
PCDHB9
protocadherin beta 9
chrX_+_119738542 4.880 NM_001137554
MCTS1
malignant T cell amplified sequence 1
chr1_-_150738292 4.877 NM_001199739
NM_004079
CTSS

cathepsin S

chr1_-_151414641 4.873 NM_207171
POGZ
pogo transposable element with ZNF domain
chrX_+_37639246 4.873 NM_000397
CYBB
cytochrome b-245, beta polypeptide
chr10_-_75193297 4.860 NM_001024593
ZMYND17
zinc finger, MYND-type containing 17
chr7_+_26400503 4.842 NM_001199837
SNX10
sorting nexin 10
chr21_-_47704166 4.820 MCM3AP
minichromosome maintenance complex component 3 associated protein
chr6_-_79675672 4.800 PHIP
pleckstrin homology domain interacting protein
chrX_-_109683457 4.790 NM_001171689
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr2_-_88285308 4.780 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr6_-_38670882 4.767 GLO1
glyoxalase I
chr2_-_43453724 4.764 ZFP36L2
zinc finger protein 36, C3H type-like 2
chr14_+_58906398 4.735 NM_001244193
KIAA0586
KIAA0586
chr6_-_38670871 4.732 GLO1
glyoxalase I
chr1_-_193075186 4.709 NM_001243399
NM_016066
GLRX2

glutaredoxin 2

chr5_+_54398473 4.692 NM_006144
GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr12_+_12966249 4.681 NM_016355
NM_201224
DDX47

DEAD (Asp-Glu-Ala-Asp) box polypeptide 47

chr7_-_64023454 4.676 NM_001130022
NM_178558
ZNF680

zinc finger protein 680

chr5_+_95997871 4.665 NM_001042440
CAST
calpastatin
chr1_-_51887740 4.652 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr10_-_16859336 4.650 RSU1
Ras suppressor protein 1
chr12_+_10460416 4.627 NM_002262
NM_007334
KLRD1

killer cell lectin-like receptor subfamily D, member 1

chr8_-_109260940 4.611 NM_001568
EIF3E
eukaryotic translation initiation factor 3, subunit E
chr2_+_74057969 4.593 STAMBP
STAM binding protein
chr3_-_113897849 4.569 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr13_+_53035227 4.548 CKAP2
cytoskeleton associated protein 2
chr5_-_137848517 4.545 ETF1
eukaryotic translation termination factor 1
chr1_+_64088886 4.483 NM_001172818
PGM1
phosphoglucomutase 1
chr17_-_47785527 4.468 SLC35B1
solute carrier family 35, member B1
chr10_-_98290309 4.459 TM9SF3
transmembrane 9 superfamily member 3
chr3_-_18480203 4.458 NM_001131010
SATB1
SATB homeobox 1
chr12_+_14538232 4.452 ATF7IP
activating transcription factor 7 interacting protein
chr2_+_37571752 4.446 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr3_-_165555167 4.443 BCHE
butyrylcholinesterase
chr1_+_6105980 4.441 NM_001199862
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr19_-_8642309 4.395 NM_012335
MYO1F
myosin IF
chr1_-_16134192 4.392 NM_001089591
UQCRHL
ubiquinol-cytochrome c reductase hinge protein-like
chr20_+_32150139 4.375 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.50 2.82e-16 GO:0044260 cellular macromolecule metabolic process
1.37 3.23e-15 GO:0044237 cellular metabolic process
1.19 4.71e-14 GO:0009987 cellular process
1.42 4.93e-14 GO:0043170 macromolecule metabolic process
1.73 6.66e-14 GO:0090304 nucleic acid metabolic process
1.34 1.99e-13 GO:0044238 primary metabolic process
1.31 2.53e-13 GO:0008152 metabolic process
1.56 5.78e-13 GO:0034641 cellular nitrogen compound metabolic process
1.60 1.50e-12 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.52 9.45e-12 GO:0006807 nitrogen compound metabolic process
1.75 5.07e-11 GO:0016070 RNA metabolic process
1.28 5.26e-11 GO:0050789 regulation of biological process
1.25 1.27e-09 GO:0065007 biological regulation
1.27 4.73e-09 GO:0050794 regulation of cellular process
1.55 8.68e-09 GO:0048522 positive regulation of cellular process
1.65 1.65e-08 GO:0010467 gene expression
1.67 3.20e-08 GO:0009059 macromolecule biosynthetic process
1.67 4.34e-08 GO:0034645 cellular macromolecule biosynthetic process
1.49 8.20e-08 GO:0048518 positive regulation of biological process
1.51 4.30e-07 GO:0006950 response to stress
1.38 4.63e-06 GO:0071840 cellular component organization or biogenesis
1.48 4.65e-06 GO:0044249 cellular biosynthetic process
2.13 6.02e-06 GO:0016071 mRNA metabolic process
1.38 9.12e-06 GO:0016043 cellular component organization
1.43 1.05e-05 GO:0071841 cellular component organization or biogenesis at cellular level
1.43 1.98e-05 GO:0071842 cellular component organization at cellular level
1.99 2.37e-05 GO:0051726 regulation of cell cycle
1.44 2.64e-05 GO:0009058 biosynthetic process
1.32 3.91e-05 GO:0051716 cellular response to stimulus
1.36 4.02e-05 GO:0060255 regulation of macromolecule metabolic process
1.45 4.73e-05 GO:0048519 negative regulation of biological process
2.69 5.36e-05 GO:0071156 regulation of cell cycle arrest
2.33 5.44e-05 GO:0010564 regulation of cell cycle process
1.96 6.93e-05 GO:0009057 macromolecule catabolic process
3.14 8.27e-05 GO:0000082 G1/S transition of mitotic cell cycle
1.46 9.20e-05 GO:0048523 negative regulation of cellular process
2.02 1.23e-04 GO:0044265 cellular macromolecule catabolic process
1.97 1.31e-04 GO:0000278 mitotic cell cycle
1.31 1.83e-04 GO:0019222 regulation of metabolic process
2.65 1.90e-04 GO:0000075 cell cycle checkpoint
3.40 2.47e-04 GO:0000077 DNA damage checkpoint
3.85 3.28e-04 GO:0000216 M/G1 transition of mitotic cell cycle
1.67 3.40e-04 GO:0010941 regulation of cell death
1.68 3.40e-04 GO:0007049 cell cycle
1.32 3.66e-04 GO:0031323 regulation of cellular metabolic process
1.52 3.76e-04 GO:0006996 organelle organization
1.77 4.53e-04 GO:0022402 cell cycle process
3.28 5.20e-04 GO:0051320 S phase
1.66 6.40e-04 GO:0042981 regulation of apoptosis
2.10 6.89e-04 GO:0016032 viral reproduction
1.39 7.36e-04 GO:0044267 cellular protein metabolic process
3.19 8.83e-04 GO:0031570 DNA integrity checkpoint
1.65 9.66e-04 GO:0043067 regulation of programmed cell death
1.82 1.03e-03 GO:0022403 cell cycle phase
2.15 1.13e-03 GO:0044419 interspecies interaction between organisms
3.20 1.47e-03 GO:0000084 S phase of mitotic cell cycle
1.68 1.51e-03 GO:0010605 negative regulation of macromolecule metabolic process
1.72 1.53e-03 GO:0033554 cellular response to stress
1.31 1.54e-03 GO:0080090 regulation of primary metabolic process
1.68 1.74e-03 GO:0031324 negative regulation of cellular metabolic process
1.64 2.25e-03 GO:0009892 negative regulation of metabolic process
1.20 2.44e-03 GO:0050896 response to stimulus
1.91 2.66e-03 GO:0006974 response to DNA damage stimulus
2.73 2.82e-03 GO:0010498 proteasomal protein catabolic process
2.73 2.82e-03 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
2.35 3.89e-03 GO:0045321 leukocyte activation
1.63 4.22e-03 GO:0032774 RNA biosynthetic process
1.80 5.28e-03 GO:0051276 chromosome organization
1.54 6.56e-03 GO:0002376 immune system process
1.55 1.07e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.29 1.10e-02 GO:0007165 signal transduction
1.51 1.45e-02 GO:0009893 positive regulation of metabolic process
1.55 1.65e-02 GO:0051246 regulation of protein metabolic process
2.13 1.72e-02 GO:0006366 transcription from RNA polymerase II promoter
2.01 1.75e-02 GO:0030163 protein catabolic process
1.65 2.02e-02 GO:0031399 regulation of protein modification process
1.53 2.05e-02 GO:0044248 cellular catabolic process
1.47 2.14e-02 GO:0009056 catabolic process
1.73 2.22e-02 GO:0006396 RNA processing
2.04 2.27e-02 GO:0051603 proteolysis involved in cellular protein catabolic process
1.57 2.78e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.55 3.14e-02 GO:0032268 regulation of cellular protein metabolic process
1.49 3.16e-02 GO:0010033 response to organic substance
2.00 3.65e-02 GO:0044257 cellular protein catabolic process
1.50 3.75e-02 GO:0031325 positive regulation of cellular metabolic process
1.93 3.83e-02 GO:0006397 mRNA processing
2.36 3.84e-02 GO:0046649 lymphocyte activation
3.52 3.97e-02 GO:0006367 transcription initiation from RNA polymerase II promoter
1.61 4.13e-02 GO:0043933 macromolecular complex subunit organization
1.25 4.17e-02 GO:0023052 signaling
2.05 4.35e-02 GO:0051325 interphase
2.04 4.72e-02 GO:0006412 translation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.20 1.93e-19 GO:0044424 intracellular part
1.19 5.16e-17 GO:0005622 intracellular
1.28 2.17e-16 GO:0005737 cytoplasm
1.25 7.14e-15 GO:0043231 intracellular membrane-bounded organelle
1.25 9.79e-15 GO:0043227 membrane-bounded organelle
1.21 6.40e-13 GO:0043229 intracellular organelle
1.21 1.08e-12 GO:0043226 organelle
1.66 2.21e-12 GO:0044428 nuclear part
1.81 2.32e-10 GO:0005654 nucleoplasm
1.67 2.96e-10 GO:0031981 nuclear lumen
1.31 8.35e-10 GO:0005634 nucleus
1.55 3.04e-09 GO:0031974 membrane-enclosed lumen
1.55 3.36e-09 GO:0043233 organelle lumen
1.55 4.76e-09 GO:0070013 intracellular organelle lumen
1.41 8.11e-09 GO:0032991 macromolecular complex
1.29 1.83e-08 GO:0044446 intracellular organelle part
1.28 7.46e-08 GO:0044422 organelle part
1.25 6.40e-07 GO:0044444 cytoplasmic part
1.37 2.32e-05 GO:0043234 protein complex
1.45 3.23e-05 GO:0005829 cytosol
1.62 1.18e-04 GO:0005783 endoplasmic reticulum
1.06 3.31e-04 GO:0044464 cell part
1.06 3.41e-04 GO:0005623 cell
1.86 3.79e-04 GO:0005694 chromosome
3.82 1.05e-03 GO:0000502 proteasome complex
1.64 7.68e-03 GO:0044451 nucleoplasm part
1.81 8.19e-03 GO:0044427 chromosomal part
6.01 9.46e-03 GO:0005839 proteasome core complex
1.75 1.13e-02 GO:0030529 ribonucleoprotein complex
3.08 1.14e-02 GO:0046930 pore complex
3.27 1.60e-02 GO:0005643 nuclear pore
2.15 2.61e-02 GO:0000228 nuclear chromosome
1.27 4.77e-02 GO:0043228 non-membrane-bounded organelle
1.27 4.77e-02 GO:0043232 intracellular non-membrane-bounded organelle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.36 7.67e-21 GO:0005515 protein binding
1.17 1.05e-14 GO:0005488 binding
1.93 9.08e-08 GO:0003723 RNA binding
2.02 1.28e-03 GO:0003712 transcription cofactor activity
2.02 1.39e-03 GO:0000988 protein binding transcription factor activity
2.02 1.39e-03 GO:0000989 transcription factor binding transcription factor activity
5.01 2.42e-02 GO:0046966 thyroid hormone receptor binding